Stars from the world of rock, pop and comedy will shake up the iconic London venue between 30 March and 3 April.
The 2012 shows will feature two of this year's Brit Awards nominated female artists, Jessie J and Florence + the Machine. Dubstep pioneer, Example, the Teenage Cancer Trust Outstanding Contribution To Music NME Award winners, Pulp and the effortlessly funny, Jason Manford plus special guests will also be taking their turn on the legendary stage.
Tickets go on sale at 9.30am Friday 24 February.
Visit www.teenagecancertrust.org for full details.